LIGHTWEIGHT GENOME VIEWER: PORTABLE SOFTWARE FOR BROWSING GENOMICS DATA IN ITS CHROMOSOMAL CONTEXT




Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability.

BACKGROUND: We have previously developed an oncolytic serotype 5 adenovirus (Ad5) with chromogranin-A (CgA) promoter-controlled E1A expression, Ad[CgA-E1A], with the intention to treat neuroendocrine tumors, including carcinoids.Since carcinoids tend to metastasize to the liver it is important to fully repress viral replication in hepatocytes to av

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